What causes the immune response, to go awry? As seen immune system is described as a highly coordinated system of cells, tissues and molecules through the animal world. The basis of the immune system is the principle of detection and elimination of foreign substances from the body, "the host lasix 5 mg animal. However, it also includes the elimination of "master" cells that are wrong, as in the case of some cancer cells. If you shot in the head and fell under the bus, your immune system is of great and immediate impact on life! In normal conditions the immune system works to the benefit of the owner - to prevent infection and cancer. However, sometimes it may seem that operates in a negative light actually cause the disease rather than prevention. This article aims to discuss and highlight the two extremes of the immune system, diseases of examples for both. Goldilocks phenomenon of violation of the human immune system can result in varying degrees of severity of impact on quality of life until his death. Often described as "Goldilocks phenomenon", the activity of the immune system can lead to violation of or does not respond fast enough or by causing the immune response is too fast. In the first case, when the immune system does not meet enough immunodeficient diseases may happen that often leads to recurrent and life threatening infections
immunodeficiency may occur for a number of sources, resulting in genetic diseases, such as in the case of severe combined immunodeficiency (SCID ), using drugs such as immunosuppressants, or infections such as acquired immunodeficiency syndrome (AIDS) is caused by retrovirus HIV. In cases where the immune system is overactive and works more efficiently than it should, the result can be an attack on normal tissues as if they were foreign organisms. This can lead to autoimmune diseases such as diabetes (type of diabetes), rheumatoid arthritis, systemic lupus erythematosus, celiac disease and allergy to name but a few. Immunodeficiency Immunodeficiency can occur if one or more components of the immune system is defective or inactive. The ability of the immune system response to pathogens is reduced as a very young and the elderly, with immune response begins to decline after 50 years on average due to the aging immune system. In developed countries, obesity, alcohol consumption and drug abuse are common causes of poor immune function. However, malnutrition is the most common cause of HIV globally due to the often poor diet of people in developing countries. Diets that do not have enough protein and lack of nutrients, such one as iron, copper, zinc, selenium, vitamins A, C, E and B6, folic acid and it has been reported to reduce immune response. In addition, decreased function of thymus at an early age through genetic mutation or surgical removal, for example, some children's Surgery can lead to severe immunodeficiency.
Immunodeficiency may also be transmitted by inheritance, such as chronic granulomatous disease (CP) is a genetic disease where patients suffer from recurrent attacks of infection due to decreased ability of phagocytes of the immune system to fight against pathogenic agents. HIV and some cancers as a result of acquired immune deficiency as a symptom. Overactive immune response, in contrast, an overactive immune system may cause a number of conditions characterized by inadequate response by the immune system. This can be either to deny the full difference between them and non-I, in the attack on the body's own tissue, as in the case of autoimmune disease, or excessive response to the environment in case of hypersensitivity. These unwanted damage and answers can be divided into four categories based on the mechanisms and timing of responses:
case studies immunodeficiency severe combined immunodeficiency (SCID), or Boy in the Bubble Syndrome is a serious, genetically inherited immunodeficiency disease in which the immune system Adaptive its totally disabled due to a defect in one of several genes. SCID included in the list of rare diseases management of rare diseases of the National Institutes of Health, which means that SCID, or subtype of SCID, affects less than 200,000 people in the U.S. population. Affected people are extremely vulnerable to infectious diseases with symptoms including chronic diarrhea, ear infections, recurrent pneumonia, and profuse oral infection Candida. Children born with SCID, if untreated, usually die within the first year because of severe, recurrent infections. Several U.S. states are pilot studies for the diagnosis of SCID in newborns (as of February 1, 2009 Wisconsin and Massachusetts screen all newborns). To date, the most common method of treatment of SCID is bone marrow transplant from the donor, preferably in the first 3 months after birth or before birth. Methods of gene therapy have been developed and, consequently, the first treatment of SCID patients occurred in 2000 and allowed these people to have a functional immune system for the first time. These studies, however, to conduct due to the increased occurrence of leukemia in these patients. Hypersensitivity example asthma is a very common chronic disease affecting the respiratory system in which the airways constrict, become inflamed and lined with excessive mucus. Often in response to one or more triggers, asthmatic response may be the result of allergens, tobacco smoke, cold or warm air, perfume, exercise, stress, to name just a few. Symptoms of asthma can vary from mild to life threatening and include wheezing, tightness in chest, itching, coughing and shortness of breath. These symptoms usually can be controlled using a combination of drugs and environmental changes after the definition of triggers. Attention in developed countries has focused on asthma because of its rapidly increasing prevalence, affecting one in four urban children. However, asthma is caused by a complex interaction of environmental and genetic factors that are not yet fully understood. By the end of 2005, 25 genes were associated with asthma in several populations. Many of these genes associated with immune system or modulyruyuschye inflammation. Autoimmune example, rheumatoid arthritis (RA) is a chronic and systemic autoimmune disorders whose causes are still not all known. This often leads to inflammation and tissue damage of the joints and tendons. RA can be disabling and painful condition that can eventually lead to a significant loss of functionality and mobility. Although currently no known cure RA treatment can relieve symptoms in some cases the change process. These procedures range from physical therapy, painkillers and anti-inflammatory drugs with immunomodulating antirheumatic drugs (DMARDs) that can be used to suppress the immune causal processes. Course of RA varies with some people with mild symptoms of short-term, but in most cases the disease is progressive and chronic. - October 2010
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